The NES and Famicom are fairly different in more ways than just overall design, but from what I can find in regards to Mega Drive and Genesis aside from what you said and some small aesthetic things there is no difference.
Just to note: the new system update is out now and it adds the quick start menu, among other things.
http://en-americas-support.nintendo.com/app/answers/detail/a_id/3070/p/431/c/267/session/L3RpbWUvMTQwMTc1NzYzMi9zaWQvLVQ3TndSVmw%3D
Mario & Luigi: Dream Team.
Started in Dream Dozing Sands, went through there, defeated Torkscrew, went through the rest, beat Robo-Drilldigger, got some beans, got some badges, went back and beat the Excellent Ten 1 challenge (finally...), and now I'm at Wakeport.
Mario & Luigi: Dream Team.
Probably the third time I've played this game for any substantial amount of time...
Anyway, just beat Bowser and Antasma at Dream's Deep.
I once had two copies of Super Mario Galaxy only because the one I had before stopped working during the ending, and I had to get another one.
Also had two copies of Bowser's Inside Story for a little bit only because I lost it, then got another copy some time later only for the one I lost to...
Because clearly people expect Mario games to take themselves completely seriously.
Some games do try to take a more serious approach, but the Mario series is pretty much the definitive example of the silly side of the scale regarding video games, and even the games that do take themselves more...